I was just looking at those things myself. I prefer the 45 because it has enough oomph to take care of any bad guy and is also powerful enough for most wild animals. That's a concern for me because me n the missus are rv'ers and sometimes we camp at Wal Mart or a truck stop while traveling but we also might camp in the mountains or backwoods.
The 45 won't be enough for large bears though, so I have thought about a 44 and I like the snubbie for carry purposes. I don't plan to hunt grizzly but if one decides to hunt me I want to be prepared. Think the snubbie would do for that? It is still a 44 magnum after all.
You might get by with the new Raging Bull with 2 inch barrel in .454 Casull caliber...that way you could use .45 Colt or the super whopper .454 casull for the Grizzly...but hate to brace a grizzly with nothing less than a bazooka RPG.