Provided the removal of the excess material does not leave any "thin" spots, on the underside of the slide.An experienced machinist worth his salt can mill a dove tail slot wide enough to mount one.
But unless he's a good friend be prepared for "sticker-shock" when you get the bill.
That’s what the outerimpact kit is for. There’s a key that fits in the existing dovetail-fixed with a set screw- and the red dot plate screws to the key.That slide is not prepped for an RMR. It just has the dovetail for a standard rear sight.