Sometimes i just need a change

For pistols, I'll generally do 3-500 in a session. Just depends on my mood or if I'm too tired to do much more. I don't develop loads with pistols. Don't care enough and the guns way more accurate than I am. Don't shoot matches and they seem to land where I'm aiming anyway so that's good enough for me. I'll usually just go somewhere around 3/4 of the way between an advertised starting load and max load and go to town. If I split it up into a couple days, I'll have more than I'll need to last me a good while before I do it all over again. I also don't load just because I have some brass laying around. I'll wait until the can gets low so I'm not shooting out the same brass all the time to keep a good rotation going.

The rifle is my money maker. I spend much more time weighing charges and getting picky for them. Never shot any official matches but I've made a few bucks on some friendly wagers

I suppose my answer would have to be no as far as the original question goes if we're talking about pistols. Rifles, yes, sometimes I need a break because it starts to get tedious and I don't like when it starts to feel like work. I like to load because it let's me get into my own little world and keeps my hands busy. If it starts to feel like work, it takes all the pleasure out of it.

Getting back on topic, with my Dillon XL650 press, I tend to go into production batches of 2000 rounds or so, depending upon Bullet Supply. I've never tired of loading any one Caliber, but that's just me.

As for W231, I tried 6 pounds of it back in the thrilling days of yesteryear, the mid 1980's. It worked great in the 9mm. In the .45 ACP, it was only okay performance. Not great.
What I found most objectionable about it in the .45 ACP, was the brilliant muzzle flash, particularly with the 185 and 200 grain SWC target loads.
Later on, I found that it could also produce lower velocity in cold weather temps. Something Match Shooters found out the hard way on a cold (45 degree F) day in Colorado, during the USPSA National Matches.
Some of them were trying to warm up their Ammunition on the hoods of their Cars to pass the Chronograph Tests for Major and Minor Power level scoring. Major Power level being the more desirable outcome.
This particular incident sent many reloaders and serious competitors scurrying away from W231 and onto other powders. Notably, the then new Vihtavouri Powders.

Now supposedly, from some of the chatter on the Internet, the formulation of W231 has been improved, to eliminate most of it's prior bad characteristics, but I've never seen any official press release from Winchester/Olin to that effect. I've not bothered to test any of the newer batches of W231, and probably won't.

While I have tested and used many different Powders in the .45 ACP, I've pretty much settled on Alliant Red Dot as my go-to powder for the bulk of my .45 ACP loading. A big plus for Alliant Red Dot is that it works in quite a few other Handgun loads, notably .38 Special, light 9mm bullet loads, my 12 gauge Trap Loads, and I've been able to find it during Political Induced shortages of Reloading Components. Not to say it's the only game in town, but it's a good one!

Also, FWIW, my favorite .45 ACP loading uses a 200 grain Berry's Plated Bullet over Red Dot for 850 fps, from the muzzle of a Tanfoglio .45 Witness or a bit more from a 1911.