The larger pistols that fit him would work well. Not that the smaller ones won't work for a house gun. They will. Just that it is easier to shoot the larger guns for most people.
The Taurus 809/800 series, full size 24/7G2s, and the PT92/PT100 fill the bill. The PT1911 single action pistols work well here ,too.
One thing that has to be considered is are there other people in the household who might need to use the same gun to defend themselves or others with? If so then something that fits all of the individuals that are qualified to shoot need to be considered.
For something smaller the 24/7 compact G2s, 800 series compacts, PT111 MillenniumG2, and the PT140G2 come into play.
The 24/7 compacts and the 800 series compacts have 3.5 in barrels compared to the PT111's 3.2" barrel. The difference may seem little but the 24/7s compacts and 800 series compacts give a little velocity boost compared to the PT111G2.
I own 5 Millennium Pro pistols but consider them more carry CCW guns more so than home defense pieces. Used as a home defense pistol is possible. I would use them for such in a pinch or if the need arised, but I have larger or mid-frame guns for that.
Just to muddy the waters if one carries at home, and I do, the Millennium series or other Taurus compacts can be with you always inside and outside the home at all times. Not bad.
The slightly larger size may also of the 24/7 and 800 series compacts would give a little more heft and size to the user to hold on and use. This would help with keeping the gun a bit more steady and help with recoil just a little bit as well.
Stay away from the mini compact guns though they could be used for house guns. They are harder to learn to shoot and be proficient with compared to their larger brethren. Remember, he or others will have to do this under great duress, loss of gross motor skills,and under adrenaline dump conditions. Having to manipulate controls on the gun under those conditions is hard at best. Yes, practice will count for a lot. The mini-compacts should be considered as a last resort but can be used if need be.
The PT709 is my only exception to that. It has some of the PT111 advantages but just in a smaller package. Recoil is subjective, but easy to control compared to some .380ACP pistols that are smaller. 9x19 has a punch the .380ACP,good as it is, just does not have. Just to muddy the waters again I own two Taurus PT58Ss and Beretta 85 in .380ACP. The longer barrels on those three .380s is much longer than the mini-compact .380s and are more user friendly than the mini-pistols. PT58s are no longer available in the States,are overseas,and the Beretta should be considered.
Newer PT58HCs are availble as used or may be new at Guns for Sale - Online Gun Auction - Buy Guns at GunBroker.com
, Guns For Sale at GunAuction.com
, or Guns For Sale, Gun Auctions, Buy and Sell Guns, Online
. Spare magazines are hard to find and a gun auction available only kind of thing.
Another thing. Whatever rounds are in the gun are more than likely what the defender will have on tap for the duration of the incident. There is not always time or does one have the means to carry spare ammo in a confrontation. A person might, but it is not always possible.
Revolvers that are midsize might be a good idea as well as the controls and manual of arms are user friendly and simple compared to semi-auto pistols.
6,7, or 8 shot models are a Taurus staple. Models 65,66,617,and 82 come to mind.