Yes, a lighter bullet with the same powder charge as a heavier bullet will result in less pressure. For instance, I load a 158 SWC .357 in front of 14.5 grains 2400. If I stick a 140 in there, I go up to 17 grains. 14.5 grains is too light and doesn't produced enough pressure for 2400 to burn cleanly using a 140 grain bullet.
At some point with slow powders loading really light charges, there are those that claim the powder can detonate, that is explode instead of burn, and produce catastrophic kabooms, but those are really light squib loads and usually applies to rifles as I understand it. Normally, less bullet weight produces less pressure, all else being the same.
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