I have a set of Crimson Trace grips on my 605 they work great have had the same set of battery's for over a year now and I shoot it on a regular basis using the laser plus practice time in the dark with it. The battery is easy to change takes less than a minute and the set I got has a softer rubber than the original Taurus grips and just a tad longer so it actually helped it fit my hand better. I also have a set of CT grips for a 1911 that I switch around to what ever 1911 I'm carrying at the moment, have had that set for over 2 years and no prob's whatsoever. Remember it's hard to hold the little dot still so don't try at first it will only drive you crazy.
Edit to add I dont think they will interfer with your speed loader, but I dont know that for sure as I use speed strips.
Edit to add I dont think they will interfer with your speed loader, but I dont know that for sure as I use speed strips.