Schofields are a lower-power, "Cowboy" load. They're as expensive or moreso than .45 Colt ammo. They're smaller, and frequently an unjacketed lead round nose or lead flat nose. They are a very light-recoil, soft-shooting round, suitable for cowboy action shooters who do trick shots with them, but not much good for much else. The .45 Colt is a lot more powerful.
I tried a .45 Schofield out of a .460 S&W revolver (a Smith & Wesson XVR) and the 180-grain bullet clocked in at around 530 feet per second. That'd be about 112 ft/lbs of energy. Not a whole lot of punch to it. Of course, you get higher velocities out of a revolver that's chambered specifically for the .45 Schofield, but even then it peaks at usually around 700 fps or so.