Rick. Please state a few facts for us to know.
What does your reload consist of? How many rounds total were sent down range? Was the gun cleaned and lubed per instructions of the manual? How fast between reloadings did you shoot. Were the rounds fired slow or rapid fire for the most part?
It's hard to start with what could have taken place without knowing some more of the details.
Grit,grime, and residue can build up under the ejector star, near the cylinder face or back, in the firing pin channel,and other places that can cause binding. Tolerances on the revolver could be that tight.
Some powders leave heavy residue in just a few shots. Even good ones that have been around for awhile.
Fast shooting for long periods or a lot of rounds downrange without a cool down period can cause this problem too.
Mechanical problems at this stage can only be guessed at without further specifics.
If parts are rubbing or binding, there should be evidence of it when the gun is cocked.
I'll let others at this stage chime in. Other wise this is going to get more lengthy than it is. ;D
Over all length of the reloads could be a factor. Some loads, even in .38 Special may be to long and rub the inside of the revolver.
Crimping of the bullets needs to be looked at too. Little ,none,or type of crimp can cause bullet setback or movement forward under the stresses of firing.
Cylinders on many makes and models on modern revolvers may be too short to take some loads.
For instance. There are Garrett loads in .44 magnum that will fit Ruger revolvers, but should not be used in Taurus, Smith& Wessons due to this. Loaded cartridges of this type as long as they are will not go in all the way into the shorter cylinders.