I would not carry a .22 mag as a primary arm, personally. But, I do often carry it in a NAA Black Widow as back up to my primary. I have 9mm and .45ACP semis and .38 and .357 magnum revolvers for carry. In that NAA, I carry Hornady CD designed for self defense in short barreled revolvers. It don't hurt that it's also quite accurate in that NAA.
I do own a 3.5" bird's head grip Heritage Rough Rider. I bought it for plinking, mostly, and have carried it with .22 mag shot loads for snakes and with CCI maximags for dispatching trapped raccoons. It takes out a coon a little faster than does a LR, or seems to.