I think as long as you're using standard practices for reloading, and staying within the parameters set forth in the reloading manual, that you're doing everything you can on your part. Now, that's not to say that a lower charge of powder might not cycle a certain type of firearm - I've read stories of lower powder charged 9mm not cycling a Glock, for example. But, I think that when you buy factory ammo, you're buying something that generically should cycle and function in most guns you shoot it in. Of course, some guns won't like this factory ammo or that factory ammo, but overall they make it to function in a broad spectrum of guns on the market. That's why you typically don't see stunning accuracy from factory ammo, unless you happen to find one that really gets along well with your particular gun.