The only knock on Unique I have is that in shorter barreled handguns, I've had issues with unburned powder ending up on my hands and arms. It's a mid-range burning powder, and quite frankly faster burning powders (of which there are many) work better in the shorter barreled pistolas.
If you still decide to use Unique, a good taper crimp may help the situation. I don't know for sure, because I stopped using it after that, but you could sure give it a try if you experience the same issue.