g-wolf: 45lcs are a large capacity cartridge, and I wouldn't fool around without an EXACT starting load.
Hodgon sells a very reasonable load manual for their powders ($10 at Barnes & Noble) or check on-line at http://www.hodgdon.com
The on-line has a really complete (and free) set of specs.
When I did load 45 LCs years ago for my Ruger BHawk, some of the hotter loads were edging up to magnum speeds. So careful there. Just my $ .02