Yes you can reverse the mag release. I am a southpaw as well. watch the video posted below. It wasn't quite as easy for me and I was afraid I was going to break something but I got it to work. I really had to push hard to get the release mechanism to get out. This makes the pt111 just a bit to being the best gun ever for me as a lefty. Now if I can only find a nice flat base plate to fit it.