In this day and age of the internet and the bear defense question being so commonly discussed, I thing the DW 460 would do very well today. It came with moon clips and any .45 auto round could be fired in it. The ACP, +P, Super, Win Mag and the .460 Rowland of course. Jim Cirillo, being the very savvy guy he was, and knowing the .460 was first an auto pistol cartridge, he talked about the better performance of the .460 Rowland from a 4" revolver, and he was right. Because powders were faster burning than those used for magnum revolver loads, the .460 gave better performance from a 4" revolver than the .44 Magnum.
IMO, a cartridge ahead of its time!