There are a number of powders you can use for 45 ACP. Tite Group is one of them and works well. You will want to try several loads with different powders to determine what gives you the best accuracy. I use Tite group for 9mm, 40SW, 38Super. 357, and 38 Special. I get good results and the real benefit is more rounds per pound generally. As always, you should consult your reloading data for the best info.