I want that extra second to have to make sure what I'm doing is the right thing. I keep the safety off so that limited fine motor skills are not required to arm my weapon. A simple draw and slide is required. I know this is against conventional wisdom. But I am not in a daily situation that I would expect to ever have to defend my life with my pistol. I carry and train for that one moment that I can't predict, and the last thing I want to do is rush and put innocent bystanders at risk from me or my assailant. Knowing that I have to chamber a round forces me to be situationally aware of my environment and always be thinking about and plan my reaction for any situation that could occur in my personal environment. Now all of the above said there are certain times when my pistol stays chambered and all that is required is a trigger pull. Home defense pistol holstered behind my nightstand and when camping or hiking in unfamiliar wilderness. Also anytime I am in unfamiliar surroundings.