Just remember that .22LR out of pistol will have less velocity and energy than out of a rifle. .22LR ammo figures are usually from being fired out of a rifle barrel.
Check this out for some pistol data to compare the .22LR and .380ACP.
.22LR - http://www.goldenloki.com/ammo/gel/22lr/gel22lr.htm
.380 ACP - http://www.goldenloki.com/ammo/gel/380acp/gel380acp.htm